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. 2015 Jun 23;11(9):1652–1667. doi: 10.1080/15548627.2015.1059558

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© 2015 Taylor and Francis Group, LLC

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Figure 6. — Functional role of CDC42 on autophagy-associated pathways. (A) Subnetwork of first-degree neighbors of CDC42 within the complemented AXAN (cAXAN). CDC42 (red diamond), prime genes (blue, signaling; black, receptors) and the formerly singleton gene DOCK8 (white) are displayed with large symbols, other AXAN genes with small symbols. (B) Effect of knockdown of ATG7 (control) and CDC42 on signaling pathways induced by autophagy activator rapamycin (Rapa). ACTB/β-actin served as loading control. (C) Effect of knockdown of CDC42 on LC3 abundance and lipidation induced by rapamycin (Rapa) in Huh7 cells.