Figure 13.

Intermittent fasting (IF) transcriptionally regulates cellular degradative, metabolic pathways, and cell death pathways. (A) Principal component analysis demonstrating markedly divergent regulation of gene transcription in hearts from lamp2 null and littermate male wild-type mice subjected to intermittent fasting or provided ad libitum access to standard chow (as in Fig. 3B–E); n = 4 to 6/group. IF stands for intermittent fasting. (B) Venn diagram depicting distribution of differentially regulated genes in wild-type and lamp2 null male mice, as compared with respective age-matched nonfasted controls, as in (A). (C) Pie chart depicting relative distribution of genes by function in intermittently fasted mice (as compared with nonfasted mice) specifically in the subset that does not overlap with genes differentially regulated in similarly treated lamp2 null mice (as in B).