Table 4.

List of top 15 GO (Gene Ontology) pathways selectively up- and downregulated only in wild-type mice subjected to intermittent fasting (vs. nonfasted controls) on a fed day

Pathway	P value	Number of genes	Fold enrichment
Upregulated genes
Proteolysis (GO:0006508)	0.015	40	1.46
Cellular macromolecule catabolic process (GO:0044265)	0.011	27	1.67
Macromolecule catabolic process (GO:0009057)	0.024	27	1.55
Modification-dependent protein catabolic process (GO:0019941)	0.002	26	1.93
Modification-dependent macromolecule catabolic process (GO:0043632)	0.002	26	1.93
Proteolysis involved in cellular protein catabolic process (GO:0051603)	0.004	26	1.83
Cellular protein catabolic process (GO:0044257)	0.004	26	1.82
Protein catabolic process (GO:0030163)	0.006	26	1.76
Oxidation reduction (GO:0055114)	0.081	25	1.40
Chromosome organization (GO:0051276)	0.011	20	1.86
DNA metabolic process (GO:0006259)	0.055	18	1.61
Chromatin organization (GO:0006325)	0.047	15	1.79
Translation (GO:0006412)	0.046	15	1.77
Regulation of cellular protein metabolic process (GO:0032268)	0.066	13	1.75
Cellular amino acid derivative metabolic process (GO:0006575)	0.004	11	2.94
Transmission of nerve impulse (GO:0019226)	0.077	11	1.83
Downregulated genes
Cytoskeleton organization (GO:0007010)	1.67E-18	29	8.69
Ion transport (GO:0006811)	5.01E-17	38	5.21
Protein localization (GO:0008104)	5.00E-13	34	7.29
Intracellular signaling cascade (GO:0007242)	4.30E-12	36	3.40
Cation transport (GO:0006812)	9.88E-12	27	5.12
Metal ion transport (GO:0030001)	6.17E-10	23	5.08
Cell death (GO:0008219)	1.45E-9	24	4.62
Apoptosis (GO:0006915)	1.59E-9	23	4.83
Establishment of protein localization (GO:0045184)	1.91E-9	27	4.02
Programmed cell death (GO:0012501)	2.18E-9	23	4.18
Death (GO:0016265)	2.28E-9	24	4.52
Regulation of apoptosis (GO:0042981)	7.63E-9	24	4.24
Protein transport (GO:0015031)	7.79E-9	26	3.90
Regulation of programmed cell death (GO:0043067)	9.67E-9	27	4.18
Regulation of cell death (GO:0010941)	1.06E-8	24	4.16