Figure 3.

(A) Splice-junction analysis of native donor and acceptor splice sites; the strength of both acceptor and donor splice sites are indicated by 8.9 bits at the nucleotide positions 109 and 228, respectively; marked by underline. The strength of other possible cryptic splice sites was also shown. (B) Splice-junction analysis of IVS4+42delG polymorphism. This polymorphism wipes out the CASS1 at nucleotide position 269 (shown by dotted arrow) and enhances the strength of the CASS2 position 274 from 2.2 bits (upper panel) to 4.0 bits (shown by dashed arrows) at nucleotide position 273 (lower panel).