Table 1.

Gene ontology (GO) functional enrichment analysis for the up- and down-regulated differentially expressed genes (DEGs) (top three pathways with lower P-values)

Category	Term	Description	Counts	P-value	Gene symbol
Up-regulated DEGs
Biological process	GO:0071218	Cellular response to misfolded protein	2	4.43E-04	ATXN3, UBE2W
Biological process	GO:0051788	Response to misfolded protein	2	9.23E-04	ATXN3, UBE2W
Biological process	GO:0006515	Misfolded or incompletely synthesized protein catabolic process	2	1.57E-03	ATXN3, UBE2W
MF	GO:0030125	Clathrin vesicle coat	2	7.52E-03	EGFR, ZAK
MF	GO:0030131	Clathrin adaptor complex	2	1.65E-02	EGFR, ZAK
MF	GO:0030119	Adaptor-related protein-type membrane coat adaptor complex	2	2.58E-02	EGFR, ZAK
CC	GO:0004709	Mitogen-activated protein kinase kinase kinase activity	3	3.26E-04	AP1G2, EGFR
CC	GO:0004702	Receptor signaling protein serine/threonine kinase activity	3	4.83E-03	AP1G2, EGFR
CC	GO:0005057	Receptor signaling protein activity	4	5.64E-03	AP1G2, EGFR
Down-regulated DEGs
Biological process	GO:0002376	Immune system process	114	6.00E-15	IL1B, TNF
Biological process	GO:0006955	Immune response	84	1.67E-14	IL1B, TNF
Biological process	GO:0006950	Response to stress	150	5.66E-14	IL1B, TNF
MF	GO:0044424	Intracellular part	369	7.77E-13	IL1B, FUS
MF	GO:0005622	Intracellular	371	1.59E-12	FUS, DDX5
MF	GO:0044444	Cytoplasmic part	239	1.30E-11	FUS, DDX5
CC	GO:0005515	Protein binding	266	1.49E-13	FUS, DDX5
CC	GO:0000166	Nucleotide binding	94	2.33E-06	FUS, DDX5
CC	GO:1901265	Nucleoside phosphate binding	94	2.38E-06	FOS, JUN

Notes: Category refers to the GO functional categories; Counts refers to the number of enriched DEGs.

Abbreviations: MF, molecular function; CC, cellular component.