Table 2.
Pathway enrichment analysis for the up- and down-regulated differentially expressed genes (DEGs) (top three pathways with lower P-values)
| Category | Term | Description | Counts | P-value | Gene symbol |
|---|---|---|---|---|---|
| Up-regulated DEGs | |||||
| KEGG | 5219 | Bladder cancer | 3 | 1.90E-03 | E2F3, EGFR |
| KEGG | 5223 | Non-small cell lung cancer | 3 | 3.91E-03 | E2F3, EGFR |
| KEGG | 5214 | Glioma | 3 | 6.59E-03 | E2F3, EGFR |
| REACTOME | 425397 | Transport of vitamins, nucleosides, and related molecules | 2 | 1.32E-02 | SLC28A3, SLCO3A1 |
| REACTOME | 190236 | Signaling by fibroblast growth factor receptor | 3 | 5.19E-02 | EGFR, IRS1 |
| REACTOME | 382551 | Transmembrane transport of small molecules | 6 | 6.40E-02 | AQP11, ATP10A |
| Down-regulated DEGs | |||||
| KEGG | 5140 | Leishmaniasis | 14 | 1.85E-07 | IL1B, TNF |
| KEGG | 4621 | Nucleotide-binding oligomerization domain-like receptor signaling pathway | 12 | 7.06E-07 | IL1B, TNF |
| KEGG | 4660 | T cell receptor signaling pathway | 16 | 1.20E-06 | FOS, TNF |
| REACTOME | 168256 | Immune system | 68 | 2.64E-08 | IL1B, DHX9 |
| REACTOME | 202403 | T-cell receptor signaling | 11 | 1.89E-06 | CD3E, GRAP2 |
| REACTOME | 1280218 | Adaptive immune system | 41 | 2.69E-06 | MAP3K8, CD3E |
Notes: Category refers to the pathway functional categories; Counts refers to the number of enriched DEGs.
Abbreviation: KEGG, Kyoto Encyclopedia of Genes and Genomes.