Table 2.
List of PEGylated protein products.
| Product | Original biologic | Therapeutic indication | Purpose of PEGylation |
|---|---|---|---|
| Adagen® (pegademase bovine) | Bovine adenosine, deamidase | Severe combined immunodeficiency (SCID) | Increased serum half-life |
| Oncaspar® (pegaspargase) | Asparaginase | Acute lymphoblastic leukemia | Increased serum half-life, less allergic reactions |
| PEG-Intron® (PEGylated IFN-α2b) | IFN-α2b | Hepatitis C | Increased serum half-life |
| Pegasys® (PEGylated IFN-α2a) | IFN-α2a | Hepatitis C | Increased serum half-life |
| Neulasta® (pegfilgrastim) | G-CSF | Neutropenia | Increased serum half-life |
| Somavert® (pegvisomant) | hGH mutein | Acromegaly | Increased serum half-life |
| MIRCERA® (PEGylated epoetin-β) | Epoetin-β | Anemia associated with chronic renal failure | Increased serum half-life |
| Cimzia® (certolizumab pegol) | Anti TNF Fab | Rheumatoid arthritis and Crohn's disease | Increased serum half-life |
| Macugen® or Macuverse® (pegaptanib) | Anti-VEGF aptamer (an RNA oligo-nucleotide) | Treatment of ocular vascular disease | Longer residence at site of action, improved efficacy |