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. 2014 Jan 24;4(1):74–78. doi: 10.1016/j.apsb.2013.12.009

Table 2.

Selected pharmacokinetic measures of TMPP in brain dialysate after intravenous, intranasal and oral administration at a dose of 10 mg/kg (mean±S.D., n=6).

Parameter i.n. i.g. i.v.
tmax (min) 15.00 20.00±5.48 15.00
Cmax (μg/mL) 0.86±0.23 0.29±0.10a 1.06±0.15
MRT (min) 82.60±19.51 110.42±30.30 101.93±24.02
AUC0−t (μg·min/mL) 45.12±7.34a 28.61±6.28a 66.25±6.69
DTE (%) 78.89 85.69 —
a

Significantly different from i.v. group, P<0.05.