Table 1.
Bone Pb levels in mice (ng Pb/mg dry wt of tibial bone) at 6 and 12 weeks on diet.
Time point | LFD | HFD | 50 ppm Pb + LFD | 50 ppm Pb + HFD |
---|---|---|---|---|
6 weeks | 0.30 ± 0.01 | 0.24 ± 0.04 | 9.95 ± 1.02a | 23.46 ± 2.47a,b |
12 weeks | 0.14 ± 0.03 | 0.10 ± 0.01 | 7.27 ± 0.47a | 14.30 ± 3.05a,b |
Data are mean ± SEM. Pb was determined in the proximal half of mineralized tibiae by atomic absorption (n = 4/group). ap < 0.05 for effect of 50 ppm Pb exposure by two-way ANOVA. bMultiplicity-adjusted p < 0.05 for interaction effect (50 ppm Pb + LFD vs. 50 ppm Pb + HFD) by two-way ANOVA with Bonferonni’s correction for multiple comparisons. |