Figure 5.

Effect of adipocyte AhR deficiency on PCB-77-induced impairment of glucose and insulin tolerance in obese mice exhibiting weight loss. After 12 weeks of HF feeding, mice of each genotype and treatment group were switched to an LF diet for 4 weeks to induce weight loss. (A) Blood glucose concentrations following a bolus of i.p.-administered glucose in mice of each genotype and treatment group following 4 weeks of weight loss. (B) Blood glucose concentrations following a bolus of i.p.-administered insulin in mice of each genotype and treatment group. For (A) and (B), *p < 0.05 compared with AhR^fl/fl within treatment group. (C) Area under the curve (AUC) for data in (A) and (D) AUC for data in (B); data are mean ± SE from n = 6–8 mice/genotype/treatment group. *p < 0.05 compared with VEH within genotype. **p < 0.05 compared with AhR^fl/fl within treatment group.