Table 2.

Parameters of formulation process in manufacturing and storage phase.

Set-up phase	Parameters evaluation
	Temperature of about 75°C guarantees a complete fusion of all excipients and absence of aggregates
Manufacturing	Sonication avoids air bubbles formation (Figure 2(a)) contributing to obtain a homogenous dispersion of diazepam powder into fused matrix
	Mould filling has been performed by analytical balance in order to uniform mass content at about 3.6 grams
Storage	Pessaries must not be exposed to solar light and they must be stored at 4°C in order to preserve diazepam activity