Table 2.
Sensitivity and regression parameters.
| Parameter | Clidinium bromide | Chlordiazepoxide |
|---|---|---|
| Optimum concentration range (μg mL−1) | 2.5–300.0 | 3.0–500.0 |
| Regression equation∗ | A CDB = 0.4592C CDB + 1.1366 | A CDZ = 1.1895C CDZ + 2.2553 |
| Correlation coefficient (n = 5) | 0.9999 | 0.9999 |
| Standard deviation of slope | 0.0019 | 0.0025 |
| Standard deviation of intercept | 0.0135 | 0.0504 |
| Regression equation∗∗ | R CDB/ALT = 0.003C CDB + 0.009 | R CDZ/ALT = 0.009C CDZ + 0.017 |
| Correlation coefficient (n = 5) | 0.9999 | 0.9999 |
| Standard deviation of slope | 1.1 × 10−5 | 2.8 × 10−5 |
| Standard deviation of intercept | 5.9 × 10−4 | 8.1 × 10−4 |
| Limit of quantification, LOQ (μg mL−1) | 0.294 | 0.403 |
| Limit of detection, LOD (μg mL−1) | 0.088 | 0.121 |
* Regression equation for the peak area of drug versus concentration of drug in μg mL−1.
∗∗Regression equation for the ratio of peak area of drug to that of I.S. versus concentration of drug in μg mL−1.