Table 4.
Characterization of in vitro deposition of final formulated and commercial DPI by ACI.
| Formulation | Particle size of dry powder [0.9]a | Angle of repose [θ] | Bulk densitya [g/cm3] | Tapped density [g/cm3] | Carr's indexa | Hausner ratioa | MMADa [μm] | GSDa [μm] | FPFa [%] |
|---|---|---|---|---|---|---|---|---|---|
| Optimized DPI (F7) | 3.059 ± 0.03 | 25 ± 0.01 | 0.076 ± 0.01 | 0.095 ± 0.02 | 20.00 ± 0.01 | 0.80 ± 0.10 | 1.16 ± 0.01 | 3.78 ± 0.07 | 56.18 ± 0.05 |
| Commercial DPI | 1.521 ± 0.04 | 24 ± 0.01 | 0.124 ± 0.01 | 0.154 ± 0.01 | 19.48 ± 0.03 | 0.80 ± 0.01 | 5.04 ± 0.03 | 1.44 ± 0.02 | 22.83 ± 0.06 |
aAll the determinations performed in triplicate and values are expressed as mean (values = average ± SD).