Table 3.
Effect of different viscosity modifiers on the in vitro transcorneal permeation of voriconazole from ophthalmic solution through freshly excised goat cornea.
| Formulations | Viscosity (cp) at 100 rpm | Amount of drug permeated in 120 mins | % in vitro permeation | P app × 10−6 (cm/s) | Corneal hydration |
|---|---|---|---|---|---|
| None | 0.98 | 0.317 ± 0.001†† | 2.12 ± 0.003†† | 30.72 ± 0.055†† | 77.88 ± 0.15 |
| PVA 1.4% | 05.43 | 0.287 ± 0.001†† | 1.918 ± 0.003†† | 26.91 ± 0.051†† | 77.63 ± 1.40 |
| CS 2% | 15.23 | 0.256 ± 0.001†† | 1.71 ± 0.003†† | 23.99 ± 0.050†† | 77.71 ± 1.48 |
| GG 1.5% | 62.66 | 0.192 ± 0.001†† | 1.281 ± 0.003†† | 17.97 ± 0.050†† | 79.36 ± 0.35 |
| SA 2% | 132.55 | 0.151 ± 0.001†† | 1.01 ± 0.001†† | 14.14 ± 0.039†† | 79.93 ± 0.38 |
| Gelrite 0.5% | 147.10 | 0.139 ± 0.001†† | 0.92 ± 0.003†† | 13.03 ± 0.055†† | 78.92 ± 0.47 |
| SCMC 2.5% | 167.80 | 0.092 ± 0.001†† | 0.61 ± 0.003†† | 8.75 ± 0.195†† | 76.68 ± 1.82 |
| XG 1.5% | 180.28 | 0.071 ± 0.001 | 0.48 ± 0.002 | 6.79 ± 0.050 | 77.53 ± 0.47 |
Values are mean ± SE of 3 solutions viscosity in each group.
†Statistically significant difference at P < 0.05; ††statistically significant difference at P < 0.01; †††statistically significant difference at P < 0.001 from control (voriconazole-HP-β-CD based solutions 1.5%, pH 7.0) as determined by one-way ANOVA followed by Dunnett's test.