Table 7.
Florey Huggins modelling of prepared formulations.
| Ratio | 1/T mmix | 1/T mpure | LHS | R | ΔH f | R/ΔH f | ϕdrug | m | 1/m | 1 − 1/m | ϕ polymer | 1 − 1/m * ϕ polymer | log(ϕ drug) | lnϕ drug + 1 − 1/m * ϕ polymer | ϕ polymer 2 | R/ΔH f(lnϕ drug + 1 − 1/m * ϕ polymer) | R/ΔH f * ϕ polymer 2 · χ | LHS | χ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F1 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | −0.537755772 | 0.001084011 | 0.001084 |
| F2 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 2 | 0.5 | 0.5 | 3 | 1.5 | 0 | 1.5 | 9 | −0.201658414 | −1.209950487 | 0.001084011 | −0.16558 |
| F3 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 3 | 0.333333 | 0.6666667 | 4 | 2.666666667 | 0 | 2.666666667 | 16 | −0.358503848 | −2.151023088 | 0.001084011 | −0.16558 |
| F4 | 0.013 | 0.01 | 0.0014 | 8.314 | 61.842 | −0.13 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | −0.537755772 | 0.001388889 | 0.001389 |
| F5 | 0.013 | 0.01 | 0.0014 | 8.314 | 61.842 | −0.13 | 1 | 2 | 0.5 | 0.5 | 3 | 1.5 | 0 | 1.5 | 9 | −0.201658414 | −1.209950487 | 0.001388889 | −0.16528 |
| F6 | 0.013 | 0.01 | 0.0014 | 8.314 | 61.842 | −0.13 | 1 | 3 | 0.333333 | 0.6666667 | 4 | 2.666666667 | 0 | 2.666666667 | 16 | −0.358503848 | −2.151023088 | 0.001388889 | −0.16528 |
| F7 | 0.013 | 0.01 | 0.0019 | 8.314 | 61.842 | −0.13 | 1 | 1 | 1 | 0 | 2 | 0 | 0 | 0 | 4 | 0 | −0.537755772 | 0.001875902 | 0.001876 |
| F8 | 0.013 | 0.01 | 0.002 | 8.314 | 61.842 | −0.13 | 1 | 2 | 0.5 | 0.5 | 3 | 1.5 | 0 | 1.5 | 9 | −0.201658414 | −1.209950487 | 0.002046784 | −0.16462 |
| F9 | 0.013 | 0.01 | 0.002 | 8.314 | 61.842 | −0.13 | 1 | 3 | 0.333333 | 0.6666667 | 4 | 2.666666667 | 0 | 2.666666667 | 16 | −0.358503848 | −2.151023088 | 0.002046784 | −0.16462 |
| F10 | 0.012 | 0.01 | 0.0008 | 8.314 | 61.842 | −0.13 | 1 | 4 | 0.25 | 0.75 | 4 | 3 | 0 | 3 | 16 | −0.403316829 | −2.151023088 | 0.000793651 | −0.18671 |
| F11 | 0.012 | 0.01 | 0.0008 | 8.314 | 61.842 | −0.13 | 1 | 5 | 0.2 | 0.8 | 5 | 4 | 0 | 4 | 25 | −0.537755772 | −3.360973575 | 0.000793651 | −0.15921 |
| F12 | 0.012 | 0.01 | 0.0012 | 8.314 | 61.842 | −0.13 | 1 | 6 | 0.166667 | 0.8333333 | 6 | 5 | 0 | 5 | 36 | −0.672194715 | −4.839801948 | 0.001234568 | −0.13765 |
| F13 | 0.012 | 0.01 | 0.0008 | 8.314 | 61.842 | −0.13 | 1 | 7 | 0.142857 | 0.8571429 | 7 | 6 | 0 | 6 | 49 | −0.806633658 | −6.587508206 | 0.000793651 | −0.12166 |
| F14 | 0.012 | 0.01 | 0.0011 | 8.314 | 61.842 | −0.13 | 1 | 8 | 0.125 | 0.875 | 8 | 7 | 0 | 7 | 64 | −0.941072601 | −8.604092351 | 0.001084011 | −0.10829 |
| F15 | 0.013 | 0.01 | 0.0015 | 8.314 | 61.842 | −0.13 | 1 | 9 | 0.111111 | 0.8888889 | 9 | 8 | 0 | 8 | 81 | −1.075511544 | −10.88955438 | 0.001547117 | −0.09722 |