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Properties of Olanzapine PLGA microspheres.
| Formulation | A | B | C | D |
|---|---|---|---|---|
| PLGA type | 75 : 25 | 50 : 50 | 65 : 35 | 75 : 25 |
| Polymer MW | 15 kDa | 30 kDa | 82 kDa | 131 kDa |
| Drug content, % | 26 | 30 | 40 | 40 |
| Bulk density, g/mL | 0.59 | 0.70 | 0.60 | 0.96 |
| Mean particle size (μm) | 17.0 | 16.8 | 22.3 | 20.6 |
| Dose of Olanzapine | 10 mg/kg | 10 mg/kg | 20 mg/kg | 20 mg/kg |
