Table 2.
Composition of indomethacin-loaded SNEDDS based on a blend of goat fat and melon oil.
| Batch | Ratio∗ O : S : CS | Goat fat (g) | Melon oil (g) | Tween 65 (g) | Tween 80 (g) | Span 85 (g) | Carbosil (mg) | Indomethacin (mg) |
|---|---|---|---|---|---|---|---|---|
| 1C | 20 : 60 : 20 | 0.4 | 0.4 | 1.2 | 1.2 | 0.8 | — | 400 |
| 1D | 20 : 60 : 20 | 0.4 | 0.4 | 1.2 | 1.2 | 0.8 | 300 | 400 |
| 2C | 35 : 45 : 20 | 0.7 | 0.7 | 0.9 | 0.9 | 0.8 | — | 400 |
| 2D | 35 : 45 : 20 | 0.7 | 0.7 | 0.9 | 0.9 | 0.8 | 300 | 400 |
| 3C | 25 : 55 : 20 | 0.5 | 0.5 | 1.1 | 1.1 | 0.8 | — | 400 |
| 3D | 25 : 55 : 20 | 0.5 | 0.5 | 1.1 | 1.1 | 0.8 | 300 | 400 |
| 4C | 25 : 60 : 15 | 0.5 | 0.5 | 1.2 | 1.2 | 0.8 | — | 400 |
| 4D | 25 : 60 : 15 | 0.5 | 0.5 | 1.2 | 1.2 | 0.8 | 300 | 400 |
*Ratio of oil blend (goat fat and melon oil) : surfactant blend (Tween 65 and Tween 80) : cosurfactant (Span 85).