Table 3.
Emulsification time of batches of indomethacin-loaded SNEDDS.
| Batch∗ | Ratio of oil blend : surfactant blend : cosurfactant∗∗ | Mean time ± S.E.M. (min) |
|---|---|---|
| 1A | 20 : 60 : 20 | 1.54 ± 0.22 |
| 1B | 20 : 60 : 20 | 2.89 ± 0.16 |
| 1C | 20 : 60 : 20 | 1.85 ± 0.14 |
| 1D | 20 : 60 : 20 | 3.52 ± 0.28 |
| 2A | 35 : 45 : 20 | 0.44 ± 0.15 |
| 2B | 35 : 45 : 20 | 2.35 ± 0.23 |
| 2C | 35 : 45 : 20 | 0.58 ± 0.08 |
| 2D | 35 : 45 : 20 | 3.63 ± 0.22 |
| 3A | 25 : 55 : 20 | 1.03 ± 0.25 |
| 3B | 25 : 55 : 20 | 3.13 ± 0.20 |
| 3C | 25 : 55 : 20 | 1.18 ± 0.33 |
| 3D | 25 : 55 : 20 | 3.33 ± 0.25 |
| 4A | 25 : 60 : 15 | 1.30 ± 0.28 |
| 4B | 25 : 60 : 15 | 2.86 ± 0.18 |
| 4C | 25 : 60 : 15 | 1.54 ± 0.37 |
| 4D | 25 : 60 : 15 | 3.79 ± 0.34 |
*A contains goat fat, B contains goat fat and carbosil, C contains goat fat with melon oil, and D contains goat fat with melon oil and carbosil. ∗∗All batches contain lipid (either goat fat or a 1 : 1 blend of goat fat with melon oil), surfactant (1 : 1 blend of Tween 60 and Tween 80), and Span 85 combined in the ratio shown above.