Table 2.
Optimized immediate release layer along with controlled release layer is formulated as bilayer tablets.
| Formulation code | F5 | F6 | F7 | F8 | F9 | F10 | F11 | F12 | F13 |
|---|---|---|---|---|---|---|---|---|---|
| Immediate release layer | |||||||||
| Pioglitazone HCl (mg) | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 | 15 |
| Crospovidone (mg) | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 |
| Avicel PH 102 (mg) | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 | 2.25 |
| Lactose (mg) | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 | 57.75 |
| Magnesium stearate (mg) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Talc (mg) | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
| Controlled release layer | |||||||||
| Metformin HCl (mg) | 500 | 500 | 500 | 500 | 500 | 500 | 500 | 500 | 500 |
| HPMC K4M (mg) | 50 | 75 | 112.5 | 125 | — | — | — | — | — |
| Guar gum (mg) | — | — | — | — | 37.5 | 75 | 112.5 | 150 | 112.5 |
| PVP K30 (mg) | 25 | 25 | 25 | 25 | 10 | 10 | 10 | 12 | 10 |
| Dicalcium phosphate (mg) | 87 | 62 | 24.5 | 12 | 114.5 | 77 | 39.5 | — | 39.5 |
| Magnesium stearate (mg) | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| Talc (mg) | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| Distilled water | — | — | — | — | Q.S | Q.S | Q.S | Q.S | Q.S |
| Barrier layer | |||||||||
| Ethyl cellulose (mg) | — | — | — | — | — | — | — | — | 35 |
| Total weight (mg) | 750 | 750 | 750 | 750 | 750 | 750 | 750 | 750 | 785 |