Table 2.
Characteristics, clinical findings, and laboratory investigations of FMF patients stratified by the presence of splenomegaly (n = 97).
| Variable | Patients with splenomegaly | Patients without splenomegaly | P value∗ |
|---|---|---|---|
| (n = 43) | (n = 54) | ||
| Male/female | 21/22 | 29/25 | 0.7 |
| Positive consanguinity | 16 (37.2%) | 15 (27.8%) | 0.4 |
| Family history of FMF | 7 (16.3%) | 7 (13%) | 0.8 |
| Age at time of study | 8.74 ± 3.59 | 8.68 ± 3.29 | 0.9 |
| Age at disease onset | 4.42 ± 2.81 | 4.92 ± 2.68 | 0.4 |
| Age at diagnosis | 6.81 ± 3.33 | 6.58 ± 3.03 | 0.7 |
| Duration between the disease onset and diagnosis | 2.25 ± 1.93 | 1.63 ± 2.07 | 0.04 |
| Frequency of attacks/month | 3.44 ± 3.00 | 3.18 ± 2.90 | 0.7 |
| Duration of attacks/day | 2.14 ± 2.07 | 1.43 ± 1.50 | 0.02 |
| Colchicine duration (years) | 2.06 ± 1.86 | 1.93 ± 1.96 | 0.6 |
| Adherence to colchicine | 21 (48.8%) | 35 (64.8%) | 0.1 |
| Abdominal pain | 42 (97.7%) | 54 (100%) | 0.4 |
| Fever | 37 (86%) | 50 (92.6%) | 0.3 |
| Arthralgia | 34 (79.1%) | 43 (79.6) | 1 |
| Chest pain | 22 (51.2%) | 45 (83.3%) | 0.001 |
| Myalgia | 18 (41.9%) | 20 (37%) | 0.7 |
| Arthritis | 17 (39.5%) | 15 (27.8%) | 0.3 |
| Convulsion | 6 (14%) | 1 (1.9%) | 0.04 |
| MPVa (fL) | 9.01 ± 2.37 | 7.48 ± 1.94 | 0.001 |
| ESRb (mm/h) | 29.37 ± 20.19 | 32.32 ± 19.59 | 0.4 |
| CRPc titer (mg/L) | 13.77 ± 11.37 | 14.89 ± 13.28 | 0.5 |
| Platelet count (×103/mm3) | 312.58 ± 75.34 | 327.32 ± 83.01 | 0.4 |
| TLCd (×103/mm3) | 7.37 ± 3.23 | 7.79 ± 3.11 | 0.5 |
| V726A allelic | 16 (18.6%) | 16 (14.8%) | 0.5 |
| M694I allelic | 10 (11.6%) | 16 (14.8%) | 0.5 |
| E148Q allelic | 8 (9.3%) | 14 (12.9%) | 0.5 |
| M694V allelic | 8 (9.3%) | 13 (12%) | 0.6 |
| M680I allelic | 7 (8.1%) | 9 (8.3%) | 1 |
| P369S allelic | 0 | 1 (0.9%) | 1 |
Quantitative data are represented as mean ± standard deviation, while qualitative data are represented as frequency (%).
∗ P value < 0.05 is significant. aMPV: mean platelet volume; bESR: erythrocyte sedimentation rate; cCRP: C-reactive protein; dTLC: total leucocytic count.