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Strategy for CNA detection used by CONSERTING. CNAs are identified through iterative analysis of (i) local segmentation by read depth (RD) within boundaries identified by structural variation (SV) breakpoints followed by (ii) segment merging and local SV analysis. Yellow vertical bars mark SV breakpoints. Dotted boxes indicate the candidate breakpoint regions for local SV analysis, which display RD changes but are not reported in global SV analysis.
