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. 2015 Oct 1;13:63. doi: 10.1186/s12951-015-0116-2

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© Wang et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — a Intracellular uptake of PLGA NP and PLGA/NR7 NP in HN6 squamous cell carcinoma. Rhodamine B was used as a fluorescent dye. The uptake is shown as a percentage of total amounts of NP (dye) incubated with the cancer cells. b Representative confocal microscopy images of targeted and non-targeted NP in HN6 cancer cells. The cells are stained with Lysotracker lysosomal stain and DAPI was used to stain the nucleus. **p < 0.01 and *p < 005 is the statistical difference between the cellular uptake of two formulations