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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Environ Sci Pollut Res Int. 2015 Apr 1;23(3):2058–2080. doi: 10.1007/s11356-015-4383-0

Table 4.

Half-life of C-PCBs in laboratory animals and humans.

PCB congener Species Gender Route of administration Half-life
Reference
t1 [days] t2 [days]
E1-PCB 911 Mice Female Oral 1.9 (Kania-Korwel et al. 2010)
E1-PCB 911 Mice Female Oral 2.7 (Kania-Korwel et al. 2010)
E1-PCB 951 Mice Female Oral 12.9 (Kania-Korwel et al. 2010)
E1-PCB 951 Mice Female Oral 6.9 (Kania-Korwel et al. 2010)
PCB 952 Wister rats Male Oral 1.43 163 (Tanabe S. 1981)
PCB 95 Humans 0.4 years4 (Agency for Toxic Substances and Disease Registry 2000, Wolff and Schecter 1991)
PCB 95 Humans 3 years4 (Agency for Toxic Substances and Disease Registry 2000, Wolff et al. 1992)
(−)-PCB 1321 Mice Female Oral 15.8 (Kania-Korwel et al. 2010)
(+)-PCB 1321 Mice Female Oral 5.1 (Kania-Korwel et al. 2010)
PCB 136 Mice Female Oral with diet 3.2 (2.1–6.9) (Mizutani et al. 1980)
(−)-PCB 1361 Mice Female Oral 8.3 (Kania-Korwel et al. 2010)
(+)-PCB 1361 Mice Female Oral 7.1 (Kania-Korwel et al. 2010)
PCB 1362 Wister rats Male Oral 2.63 (Tanabe S. 1981)
PCB 136 Beagles (dog) Male i.v. 0.05 3.05 (Sipes et al. 1982)
PCB 136 Sprague-Dawley rats i.v. 0.24 3.6 (Matthews and Tuey 1980)
PCB 136 Sprague- Dawley rats Male i.v. 0.44 (Birnbaum 1983)
PCB 136 Cynomolgus monkey Male i.v. 0.16 4.57 (Sipes et al. 1982)
(−)-PCB 1491 Mice Female Oral 11.7 (Kania-Korwel et al. 2010)
(+)-PCB 1491 Mice Female Oral 7.5 (Kania-Korwel et al. 2010)
(−)-PCB 1741 Mice Female Oral 11.2 (Kania-Korwel et al. 2010)
(+)-PCB 1741 Mice Female Oral 11.4 (Kania-Korwel et al. 2010)
(−)-PCB 1761 Mice Female Oral 0.54 (Kania-Korwel et al. 2010)
(+)-PCB 1761 Mice Female Oral 1.2 (Kania-Korwel et al. 2010)
PCB 1762 Wister rats Male Oral 3.13 >903 (Tanabe S. 1981)
PCB 1831 Mice Female Oral 6.9 (Kania-Korwel et al. 2010)
PCB 1832 Wister rats Male Oral 9.33,5 >903,5 (Tanabe S. 1981)
PCB 1836 Rhesus monkey (Macaca mulatta) Female Oral 0.63 years (0.33–1.00 years) (Mes et al. 1995)
PCB 183 Humans 0.13 years7 (Agency for Toxic Substances and Disease Registry 2000, Luotamo et al. 1991b)
PCB 183 Humans 7.9 years8 (Agency for Toxic Substances and Disease Registry 2000, Wolff et al. 1992)
1

Female C57Bl/6 mice received 50 mg/kg body weight of a PCB mixture containing racemic PCB 91 (6.1% by weight), PCB 95 (24.5% by weight), PCB 132 (12.7% by weight), PCB 136 (4.7% by weight), PCB 149 (30.5% by weight), PCB 174 (13.4% by weight), PCB 176 (1.6% by weight) and PCB 183 (6.5% by weight) in corn oil (5.0 mg PCB/ml corn oil) by oral gavage (Kania-Korwel et al. 2010).

2

A equivalent mixture of Kanechlor-300, -400, -500 and -600 (3 mg in 1 mL corn oil) was orally administered each day for 5 days (Tanabe S. 1981);

3

half-life of the total PCB content in the animals;

4

co-eluting PCBs 95, 56 and 60;

5

co-eluting PCBs 174 and 183;

6

Aroclor 1254 was administered daily for six years, followed by a deplete period of three years. For additional experimental details see (Mes et al. 1995);

7

adipose tissue;

8

co-eluting PCBs 128 and 183; E1 = first eluting PCB atropisomer; E2 = second eluting PCB atropisomer.