Table 5. Correlations between serum concentrations of dioxin congeners and parameters of laboratory and physiological tests in the subjects working for waste incineration facilities.
| Median | Min | Max | Pearson’s correlation coefficient | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PCDDs | PCDFs | Coplanar PCBs | Total dioxins | |||||||||
| Physiological test | ||||||||||||
| SBP (mmHg) | 133 | 74 | 233 | –0.0097 | 0.0118 | 0.0985 | * | 0.0375 | ||||
| DBP (mmHg) | 81 | 40 | 127 | 0.0488 | 0.0695 | 0.1435 | ** | 0.0961 | * | |||
| Heart rate (count/min) | 75 | 48 | 135 | 0.0324 | –0.0347 | 0.0570 | 0.0251 | |||||
| Blood cell count | ||||||||||||
| WBC (count/μl) | 6,800 | 3,220 | 14,100 | 0.0306 | –0.0049 | –0.0646 | –0.0143 | |||||
| RBC (×104 count/μl) | 483 | 357 | 629 | 0.0077 | –0.0309 | 0.0110 | –0.0061 | |||||
| Hb (g/dl) | 15.3 | 11.9 | 19.8 | 0.0256 | –0.0130 | 0.0725 | 0.0360 | |||||
| HT (%) | 44.8 | 31.7 | 58.8 | 0.0093 | –0.0256 | 0.0276 | 0.0058 | |||||
| PLT (×104 count/μl) | 23.8 | 3.8 | 43.8 | –0.0593 | –0.0951 | –0.1067 | ** | –0.0946 | * | |||
| Blood chemistry test | ||||||||||||
| TP (g/dl) | 7.2 | 5.9 | 9.2 | 0.0613 | 0.0932 | * | 0.1024 | ** | 0.0864 | * | ||
| Alb (g/dl) | 4.7 | 3.8 | 5.8 | 0.0233 | 0.0802 | * | 0.1002 | ** | 0.0686 | |||
| T-bil (mg/dl) | 0.6 | 0.2 | 5.1 | –0.0246 | 0.0439 | 0.0909 | * | 0.0402 | ||||
| AST (IU/l) | 23 | 11 | 131 | 0.0262 | 0.0168 | 0.1610 | ** | 0.0818 | ||||
| ALT (IU/l) | 25 | 6 | 224 | 0.0331 | –0.0100 | 0.1507 | ** | 0.0663 | ||||
| LDH (IU/l)1 | 216 | 96 | 1,174 | 0.0080 | 0.0176 | 0.0461 | 0.0188 | |||||
| LDH (IU/l)2 | 170 | 119 | 363 | –0.0673 | –0.0098 | –0.0706 | –0.0633 | |||||
| ALP (IU/l) | 219 | 83 | 730 | –0.0523 | –0.0680 | –0.0373 | –0.0595 | |||||
| LAP (IU/l) | 55 | 23 | 192 | 0.0313 | –0.0090 | 0.1193 | ** | 0.0585 | ||||
| GGT (IU/l) | 38 | 10 | 1,133 | 0.0530 | 0.0060 | 0.1946 | ** | 0.1033 | ** | |||
| AMY (IU/l) | 70 | 25 | 231 | –0.0503 | –0.0746 | –0.0817 | * | –0.0777 | * | |||
| CK (IU/l) | 119 | 35 | 3,087 | 0.0508 | 0.0703 | 0.0428 | 0.0598 | |||||
| Fe (μg/dl) | 101 | 21 | 277 | 0.0314 | 0.0506 | 0.0922 | * | 0.0608 | ||||
| BUN (mg/dl) | 13 | 6 | 24 | 0.0227 | 0.0506 | 0.0881 | * | 0.0579 | ||||
| UA (mg/dl) | 5.7 | 2.7 | 10.7 | 0.0250 | –0.0263 | 0.0884 | * | 0.0336 | ||||
| Cr (mg/dl) | 0.8 | 0.4 | 1.5 | –0.0530 | –0.0209 | –0.0863 | * | –0.0629 | ||||
| T-ch (mg/dl) | 199 | 99 | 385 | 0.0329 | –0.0232 | 0.0517 | 0.0166 | |||||
| HDL-ch (mg/dl) | 53 | 17 | 131 | –0.0184 | 0.0090 | 0.0197 | 0.0006 | |||||
| TG (mg/dl) | 121 | 31 | 2363 | 0.0155 | –0.0523 | 0.0998 | * | 0.0317 | ||||
| BS (mg/dl) | 95 | 63 | 446 | 0.0440 | –0.0306 | 0.1042 | ** | 0.0559 | ||||
| HbA1c (%) | 4.8 | 2.1 | 11.8 | 0.0917 | * | 0.0961 | * | 0.0525 | 0.0906 | |||
| Immunological function test | ||||||||||||
| PHA (cpm) | 38,774 | 2,275 | 60907 | –0.0791 | * | –0.1121 | ** | –0.0102 | –0.0702 | |||
| ConA (cpm) | 32,095 | 1,595 | 64,400 | –0.0148 | 0.0064 | 0.0091 | –0.0027 | |||||
| PHA-SI3 | 122.2 | 4.0 | 606.2 | –0.0279 | –0.1140 | ** | 0.0208 | –0.0330 | ||||
| ConA-SI4 | 99.5 | 2.8 | 334.8 | 0.0028 | –0.0542 | –0.0320 | 0.0007 | |||||
| NKACT (%) | 38.0 | 5.0 | 79.0 | –0.0062 | 0.0269 | 0.0416 | 0.0238 | |||||
| CD3 (%) | 72.6 | 43.1 | 89.2 | –0.0407 | –0.0344 | –0.0509 | –0.0510 | |||||
| CD4 (%) | 45.2 | 14.9 | 74.6 | –0.0202 | –0.0569 | –0.0449 | –0.0405 | |||||
| CD8 (%) | 29.3 | 10.5 | 60.8 | 0.0146 | 0.0661 | 0.0295 | 0.0339 | |||||
| CD4/CD8 ratio | 1.6 | 0.3 | 5.6 | –0.0190 | –0.0699 | –0.0406 | –0.0413 | |||||
| CD19 (%) | 8.6 | 0.5 | 25.9 | 0.0417 | 0.0421 | –0.0380 | 0.0121 | |||||
| CD56 (%) | 16.1 | 3.1 | 48.7 | –0.0183 | 0.0369 | 0.0600 | 0.0448 | |||||
Adjusted for age, survey year, BMI, smoking habits and alcohol consumption. *p<0.05, **p<0.01. 1,2The LDH data measured at Rousai Hospitals were adjusted as described in Subjects and Methods. 3,4SI indicates the Stimulation Index. SBP: Systolic blood pressure; DBP: Diastolic blood pressure; WBC: White blood cell; RBC: Red blood cell; Hb: Hemoglobin; Ht: Hematocrit; PLT: Platelet; TP: Total protein; Al: Albumin; T-bil: Total bilirubin; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; LDH: Lactate dehydrogenase; ALP: Alkaline phosphatase; LAP: Leucine aminopeptidase; GGT: Gamma-glutamyltransferase; AMY: Amylase; CK: Creatine kinase; Fe: Ferrum (iron); BUN: Blood urea nitrogen; UA: Urinary acid; Cr: Creatinine; T-cho: Total cholesterol; HDL-ch: High-density lipoprotein cholesterol; TG: Triglyceride; BS: Blood sugar; HbA1c: Hemoglobin-A1c; PHA: Lymphocyte blastoid transformation by Phytohemaggutinin; ConA: Lymphocyte blastoid transformation by Concanavalin A; NKACT: Natural killer cell activity; CD: Cluster of differentiation