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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Schizophr Res. 2015 Jul 8;168(0):402–410. doi: 10.1016/j.schres.2015.06.023

Fig. 6.

Fig. 6

Glutamate exposure upregulates Zfp804a, Pde4b, and Comt expression but decreases levels of Drd2 expression. Plots show quantitative PCR results performed on cultures of rat primary cortical neurons collected at embryonic day 19. All results normalized to the reference gene Hprt1. (A) Cortical neurons exposed to glutamate [20μM] show increased Zfp804a expression. The NMDA receptor antagonist MK-801 blocked this increase. Glutamate exposure led to a four-fold increase in the expression of Pde4b (B) and a two-fold increase in Comt (C) levels in cortical neurons (Student's t-test, . Both increases were blocked by MK-801. (D) Levels of Drd2 were significantly decreased by glutamate exposure, but not in the presence of MK-801. Mean and SEM of three experiments is shown; Mann-Whitney, *P<0.05, **, P<0.01.