Table 2.
Probe sets indicating increased expression of genes in orbital adipose tissues from subjects with GPA.
| Set 1 | Set 2 | ||||
|---|---|---|---|---|---|
| Probe Set | Gene Title | Fold Difference |
FDR P- value |
Fold Difference |
FDR P- value |
| 209875_s_at | secreted phosphoprotein 1 | 56.68 | 7.04E-04 | 54.74 | 2.51E-03 |
| 214677_x_at | immunoglobulin λ constant 1 (Mcg marker) |
9.35 | 9.63E-03 | 58.44 | 1.11E-03 |
| 216491_x_at | immunoglobulin heavy constant mu | 15.85 | 1.30E-03 | 41.14 | 3.77E-04 |
| 214669_x_at | immunoglobulin κ constant | 13.28 | 3.77E-04 | 41.10 | 7.07E-04 |
| 215379_x_at | immunoglobulin λ variable 1-44 | 8.33 | 3.30E-03 | 36.77 | 1.38E-03 |
| 209396_s_at | chitinase 3-like 1 (cartilage glycoprotein-39) |
20.75 | 2.12E-04 | 10.78 | 2.16E-02 |
| 214973_x_at | immunoglobulin heavy constant delta | 12.44 | 3.35E-04 | 15.87 | 6.54E-03 |
| 202834_at | angiotensinogen (serpin peptidase inhibitor, clade A, member 8) |
12.04 | 1.18E-03 | 8.18 | 4.06E-02 |
| 1555745_a_at | lysozyme | 9.04 | 2.47E-03 | 10.53 | 1.83E-02 |
| 1555756_a_at | C-type lectin domain family 7, member A |
10.12 | 1.38E-02 | 8.19 | 3.73E-02 |
| 211429_s_at | serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 1 |
11.48 | 1.75E-04 | 6.31 | 3.80E-02 |
| 205267_at | POU class 2 associating factor 1 | 10.59 | 1.47E-03 | 7.01 | 1.47E-02 |
| 219386_s_at | SLAM family member 8 | 11.25 | 8.00E-06 | 5.80 | 3.41E-02 |
| 211919_s_at | chemokine (C-X-C motif) receptor 4 | 8.67 | 1.13E-02 | 7.30 | 7.46E-03 |
| 203936_s_at | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) |
10.40 | 2.16E-05 | 4.75 | 1.54E-02 |
| 204116_at | interleukin 2 receptor, γ | 8.62 | 9.70E-04 | 5.94 | 1.70E-02 |
| 217235_x_at | immunoglobulin λ-like polypeptide 5 | 6.24 | 7.73E-03 | 8.23 | 1.51E-02 |
| 219890_at | C-type lectin domain family 5, member A |
7.85 | 1.70E-06 | 5.68 | 6.26E-03 |
| 210072_at | chemokine (C-C motif) ligand 19 | 8.99 | 1.37E-04 | 4.07 | 4.51E-02 |
| 224342_x_at | BMS1 homolog, ribosome assembly protein (yeast) pseudogene |
6.29 | 2.66E-03 | 5.59 | 4.79E-02 |
| 222838_at | SLAM family member 7 | 5.30 | 4.72E-03 | 6.46 | 3.09E-02 |
| 1555349_a_at | integrin, β 2 (complement component 3 receptor 3 and 4 subunit) |
6.57 | 2.61E-04 | 5.06 | 7.82E-03 |
| 1558199_at | fibronectin 1 | 4.89 | 2.41E-02 | 6.07 | 6.71E-03 |
| 205798_at | interleukin 7 receptor | 6.15 | 1.21E-02 | 4.42 | 1.78E-02 |
| 213193_x_at | T cell receptor β constant 1 | 4.96 | 3.31E-03 | 5.37 | 1.81E-02 |
| 220306_at | family with sequence similarity 46, member C |
4.28 | 3.16E-02 | 6.01 | 2.99E-02 |
| 205997_at | ADAM metallopeptidase domain 28 | 6.21 | 4.19E-03 | 3.80 | 4.67E-02 |
| 1552806_a_at | sialic acid binding Ig-like lectin 10 | 5.43 | 8.53E-05 | 3.35 | 4.11E-02 |
| 233510_s_at | parvin, γ | 5.44 | 5.90E-04 | 3.20 | 5.80E-03 |
| 211881_x_at | immunoglobulin λ joining 3 | 3.10 | 4.14E-02 | 5.53 | 2.30E-02 |
| 211908_x_at | immunoglobulin κ locus | 3.52 | 1.58E-02 | 5.11 | 8.75E-04 |
| 205213_at | ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 |
4.85 | 6.72E-03 | 3.48 | 1.37E-03 |
| 207794_at | chemokine (C-C motif) receptor 2 | 4.38 | 1.22E-02 | 3.40 | 1.82E-02 |
| 212657_s_at | interleukin 1 receptor antagonist | 4.06 | 8.97E-03 | 3.69 | 4.68E-03 |
| 229041_s_at | ITGB2 antisense RNA 1 | 4.05 | 1.73E-03 | 3.68 | 3.71E-02 |
| 215946_x_at | immunoglobulin λ-like polypeptide 3, pseudogene |
3.68 | 4.55E-02 | 3.78 | 2.39E-02 |
| 226658_at | podoplanin | 3.28 | 1.54E-02 | 4.13 | 2.46E-02 |
| 222858_s_at | dual adaptor of phosphotyrosine and 3-phosphoinositides |
4.07 | 1.40E-03 | 3.32 | 3.07E-02 |
| 204852_s_at | protein tyrosine phosphatase, non-receptor type 7 | 3.90 | 2.36E-04 | 3.44 | 3.27E-03 |
| 1552960_at | leucine rich repeat containing 15 | 3.66 | 2.53E-02 | 3.64 | 1.51E-02 |
| 211991_s_at | major histocompatibility complex, class II, DP α 1 |
3.21 | 2.22E-02 | 4.08 | 5.08E-03 |
| 229721_x_at | derlin 3 | 3.87 | 8.11E-03 | 3.21 | 2.40E-02 |
| 1552497_a_at | SLAM family member 6 | 3.30 | 4.60E-03 | 3.75 | 1.87E-03 |
| 224310_s_at | B-cell CLL/lymphoma 11B (zinc finger protein) |
3.65 | 4.56E-02 | 3.25 | 8.32E-04 |
| 209696_at | fructose-1,6-bisphosphatase 1 | 3.32 | 2.01E-02 | 3.57 | 2.58E-02 |
| 210423_s_at | solute carrier family 11 (proton- coupled divalent metal ion transporters), member 1 |
3.48 | 3.64E-03 | 3.32 | 1.89E-02 |
| 1553863_at | WDFY family member 4 | 2.98 | 5.10E-03 | 3.68 | 3.86E-05 |
| 219971_at | interleukin 21 receptor | 2.88 | 4.59E-02 | 3.65 | 1.61E-03 |
| 228658_at | myocardial infarction associated transcript (non-protein coding) |
3.25 | 2.39E-02 | 3.21 | 8.95E-03 |
| 202856_s_at | solute carrier family 16, member 3 (monocarboxylic acid transporter 4) |
2.76 | 8.22E-03 | 3.46 | 1.55E-03 |
Shown here are 50 probe sets with the highest fold differences compared to uninflamed control tissues and with adequate annotation. For genes interrogated by multiple probe sets, only the one with the highest fold difference is listed here. The entire list of probe sets with significantly higher signals is in Supplemental Table 1.