Table 2.

Mean Effect Size of Improvement in Cognitive Function by COMT genotype.

Dependent Variable Effect Size	COMT Genotype	Mean Effect Size	Std. Error	F (p)
Processing Speed	Met/Met	0.310	0.078	F(2,129) = 1.320 (p = 0.271)
	Val/Met	0.327	0.055
	Val/Val	0.442	0.059
Attention/Vigilance	Met/Met	0.021	0.115	F(2,129) = 4.703 (p = 0.011)**
	Val/Met	−0.369	0.082
	Val/Val	−0.386	0.087
Working Memory	Met/Met	0.028	0.122	F(2,129) = 0.864 (p = 0.424)
	Val/Met	−0.054	0.086
	Val/Val	0.112	0.092
Verbal Learning	Met/Met	0.183	0.039	F(2,129) = 6.116 (p = 0.003)*
	Val/Met	0.173	0.028
	Val/Val	0.045	0.030
Visual Learning	Met/Met	0.314	0.060	F(2,129) = 4.446 (p = 0.014)**
	Val/Met	0.222	0.043
	Val/Val	0.097	0.046
Reasoning & Problem Solving	Met/Met	0.029	0.064	F(2,129) = 0.111 (p = 0.895)
	Val/Met	0.066	0.045
	Val/Val	0.054	0.048
Global Composite Index	Met/Met	0.024	0.060	F(2,129) = 0.108 (p = 0.898)
	Val/Met	0.064	0.046
	Val/VAl	0.055	0.050

^*Bonferroni corrected p ≤ 0.008 (i.e., p value of 0.05/6 domains),

^**uncorrected p value p ≤ 0.05