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. Author manuscript; available in PMC: 2016 Sep 1.
Published in final edited form as: Eur J Pharm Biopharm. 2015 Jun 12;95(0 0):27–39. doi: 10.1016/j.ejpb.2015.05.022

Figure 3.

Figure 3

Representative chemical structures of polysaccharide-based sealants. (A) Deacetylation of chitin generates chitosan with different degrees of acetylation, and various chemically modified chitosan derivatives are obtained by reacting chitosan with (i) lactobionic acid, (ii) 4-azidobenzoic acid, (iii) succinic anhydride, ((iv) PEG oligomers, (v) N-acetylcysteine, and (vi) 3-mercaptopropionic acid at the amine site [51–57]. (B) Preparation of aldehyde-containing dextran via selective partial oxidation by periodide [60, 61]. (C) Chemical modification of chondroitin sulfate to introduce (i) methacrylate groups via reacting with glycidyl methacrylate [63], (ii) aldehyde groups via the oxidation reaction by periodide [64], and (iii) NHS-activated ester groups [66].