Table 2.

Use of local and systemic antibiotics in patients undergoing APR with primary perineal closure

Included studies	n	Local antibiotics			Systemic antibiotics
First author		Local (Yes/no)	Type	Location	Pre-operative	Post-operative
Collin et al. [7]	52	Yes	Genta sulfate sponge 2.0 mg/m2 (Collatamp)	Perineal wound	Prophylaxis not specified	Not specified n (%): 11 (21)
	50	No	–	–	Prophylaxis not specified	Not specified n (%): 11 (22)
De Bruin et al. [8]	19	Yes	Genta sponge (Garacol), 3 per patient	Sacral cavity	Augmentin 1 × 1000/200 mg	–
	21	No	–	–	Augmentin 1 × 1000/200 mg	–
Gruessner et al. [11]	49	Yes	Genta sponge (Septocoll), 3 per patient	Sacral cavity	Cefa 1 × 2 g, metro 1 × 500 mg	–
	48	No	–	–	Cefa 1 × 2 g, metro 1 × 500 mg	–
Rosen et al. [27]	22	Yes	Genta-PMMA, 30 beads, 1 chain per patient	Sacral cavity	Cefa 1 × 2 g, metro 1 × 500 mg	Cefa 2 × 2 g, metro 2 × 500 mg; day of operation
	22	No	–	–	Cefa 1 × 2 g, metro 1 × 500 mg	Cefa 2 × 2 g, metro 2 × 500 mg; day of operation
Moesgaard et al. [17]	41	Yes	Injection 160 mg genta/400 mg metro	Perineal wound	Genta 1 × 80 mg, metro 1 × 500 mg	Genta 3 × 80 mg, metro 3 × 500 mg; 2 days
	38	No	–	–	Genta 1 × 80 mg, metro 1 × 500 mg	Genta 3 × 80 mg, metro 3 × 500 mg; 2 days
Sachweh et al. [30]	80	Yes	Genta-PMMA, 30 beads, 2 chains per patient	Sacral cavity	–	–
	26	No	–	–	–	–
Mühleder et al. [19]	67	Yes	Genta-PMMA, 1 chain per patient	Perineal wound	Paro 4 × 500 mg, metro 3 × 500 mg orally	Metro 3 × 500 mg; 3 days
	42	No	–	–	–	–
Lütje et al. [15]	25	Yes	Genta PMMA 30-beads (Septopal), 1 chain per patient	Perineal wound	Latamoxef 1 × 2 g	Latamoxef 1 × 2 g 12 h after incision

Cefa cefazolin, Metro metronidazole, Paro paromomycin, Genta gentamicin