Figure 1.
Altered modulation of the IL-8 signaling pathway in AH livers with MDBs. Changed expression of the IL-8 signaling pathway was shown at the transcriptional level in AH livers compared with normal livers. The altered modulation of the IL-8 signaling pathway components contribute to the constitutive hyperactivation of this pathway, resulting the cell viability, inflammation and respiratory burst as shown in diagram. The red symbols indicate the genes with relative higher expression in alcoholic hepatitis vs normal livers.