. Author manuscript; available in PMC: 2016 Oct 1.

Published in final edited form as: Exp Mol Pathol. 2015 Aug 8;99(2):320–325. doi: 10.1016/j.yexmp.2015.08.002

Table 1.

IL-8 signaling is deregulated in AH livers with MDBs.

IPA category	Pathway −log (P-value^a)	Gene symbol	Molecules in dataset	Ratio
BRCA1-mediated	1.41E00	CXCR2	Chemokine (C-X-C motif) receptor 2	6.56E-02
		NOX4	NADPH oxidase 4
		FLT4	Fms-related tyrosine kinase 4
		BCL-2	B-cell CLL/lymphoma 2
		MAP2K1	Mitogen-activated protein kinase kinase 1
		ATM	ATMserine/threonine kinase
		BAX	BCL-2 associated X protein
		PIK3CB	Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
		GNG11	Guanine nucleotide binding protein (G protein), gamma11
		GNG2	Guanine nucleotide binding protein (G protein), gamma 2
		GNAI1	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
		LIMK2	LIM domain kinase 2
		PTGS2	prostaglandin-endoperoxide synthase 2

Abbreviations: FDR, false discovery rate; IPA, ingenuity pathway analysis.

Fischer’s exact test was used to calculate the P-value, determining the probability that the association between the genes in the data set and the canonical pathway is explained by chance alone. To account for multiple canonical pathways tested by IPA, the FDR option was used (FDR<0.1).