Table 4.
Univariate analysis and variables associated with ICU mortality
| Variables | Survivors (n = 372) | Dead (n = 68) | p |
|---|---|---|---|
| Age med (IQR) | 68 (60–73) | 70 (62–76) | 0.031 |
| Gender (M/F) | 313/58 | 59/10 | 1.000 |
| Time course of COPD (years) med (IQR) | 7 (4–15) | 8.5 (3.5–15) | 0.506 |
| FEV1 (ml) med (IQR) | 860 (700–1070) | 900 (775–1030) | 0.489 |
| Diabetes n (%) | 69 (18.6) | 12 (17.4) | 1.000 |
| Cardiovascular comorbidities n (%) | 107 (28.8) | 27 (39.1) | 0.116 |
| Oxygen home therapy n (%) | 77 (34) | 16 (29.3) | 0.495 |
| SAPS II med (IQR) | 27 (21–34) | 32 (26–37) | 0.003 |
| pH at admission med (IQR) | 7.29 (7.24–7.33) | 7.25 (7.19–7.30) | 0.001 |
| NIV at admission n (%) | 266 (71.7) | 20 (29) | <0.001 |
| Invasive ventilation at admission n (%) | 105 (28.3) | 49 (71) | <0.001 |
| NIV failure n (%) | 24 (9) | 16 (80) | <0.001 |
| Empiric antibiotic therapy at ICU admission n (%) | 210 (56.6) | 38 (55.1) | 0.895 |
| Bronchodilators n (%) | 204 (79.7) | 37 (78.7) | 0.846 |
| Systemic corticosteroids n (%) | 121 (33.2) | 30 (44.1) | 0.097 |
| VAP n (%) | 23 (6.1) | 38 (55.1) | <0.001 |
COPD chronic obstructive pulmonary disease, FEV 1 forced expiratory volume in 1 s, SAPS Simplified Acute Physiology Score, NIV non-invasive ventilation, VAP ventilator associated pneumonia, med median, IQR inter-quartile range
Variables with p value < 0.2 are presented in italic