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. Author manuscript; available in PMC: 2016 Oct 29.
Published in final edited form as: Neuroscience. 2015 Aug 24;307:128–137. doi: 10.1016/j.neuroscience.2015.08.037

Fig. 2.

Fig. 2

Effects of BACE1 haploinsufficiency on APP processing in male and female 5XFAD mice at 6–7 months of age. (A) Representative immunoblots of protein extracts from hemibrain homogenates of male (M) and female (F) mice. (B–G) Immunoreactive bands were quantified and expressed as the percentage of male 5XFAD controls (n = 3–6 mice per group). BACE1 haploinsufficiency significantly reduced BACE1, C99 and sAPPβ with the Swedish mutation (sAPPβ-Swe) in 5XFAD mice, whereas it increased full-length APP and sAPPα (*p < 0.05 vs. 5XFAD). There was no significant sex difference in these changes observed in BACE1+/−·5XFAD mice as well as baseline values in 5XFAD controls. All data are presented as mean ± S.E.M.