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. 2015 Oct 1;10(10):e0138852. doi: 10.1371/journal.pone.0138852

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© 2015 Herold et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 1 — After sacrificing the animals, eyes were enucleated from the animals immunized with myelin oligodendrocyte glycoprotein (MOG) (A) and from the group of animals with optic nerve transection (ONT) (B), at early (day 7 post MOG-immunization (MOG_7dpi) or day 7 after ONT (ONT_7)) and late time points (day 1 of experimental autoimmune encephalomyelitis (d1EAE) or day 14 after ONT (ONT_14)). Retinal ganglion cells (RGCs) were isolated using laser capture microdissection (LCM) and a global transcriptome analysis was performed. Selection of relevant pathways and network specific for MOG-EAE was detected using Ingenuity Pathway Analysis (IPA).