Table 1. Allele-wise association analysis of the investigated WFS1 SNPs and diabetes mellitus.

	T1DM						T2DM						DM
SNP, Risk allele	Freq. T1DM	Freq. Control	p	OR	Lower CI	Upper CI	Freq. T2DM	Freq. Control	p	OR	Lower CI	Upper CI	Freq. DM	Freq. Control	p	OR	Lower CI	Upper CI
rs6824720, G	0.841	0.812	0.145	1.221	0.933	1.597	0.875	0.824	0.004	1.505	1.137	1.990	0.858	0.824	0.027	1.293	1.029	1.624
rs10010131, G	0.639	0.605	0.134	1.154	0.957	1.393	0.689	0.609	2.5∙10 −4	1.425	1.178	1.722	0.664	0.608	0.002	1.270	1.090	1.480
rs13147655, G	0.649	0.599	0.052	1.233	0.998	1.523	0.689	0.606	4.5∙10 −4	1.444	1.176	1.774	0.669	0.606	0.002	1.317	1.108	1.566
rs1801208, G	0.959	0.958	0.883	1.039	0.627	1.720	0.956	0.950	0.550	1.151	0.725	1.828	0.958	0.950	0.352	1.204	0.814	1.782
rs1046320, A	0.598	0.589	0.675	1.038	0.871	1.237	0.674	0.592	1.1∙10 −4	1.429	1.191	1.714	0.635	0.591	0.011	1.205	1.044	1.390
rs1046322, A	0.187	0.090	3.9∙10 −11	2.327	1.802	3.004	0.139	0.094	0.001	1.555	1.191	2.032	0.163	0.094	5.9∙10 −9	1.887	1.520	2.343
rs9457, C	0.601	0.544	0.008	1.264	1.062	1.504	0.631	0.546	8.1∙10 −5	1.421	1.193	1.698	0.616	0.546	5.1∙10 −5	1.334	1.160	1.533

Tests were carried out using an allele-wise approach. p: p value of statistical significance of the χ ²-probe. Bold numbers show nominally significant results, underlined p values are significant using FDR approach, whereas double underlined numbers mean significant results after Bonferroni correction for multiple testing. Freq.: allele frequencies, OR, Lower CI, Upper CI: Odds-ratio with 95% upper and lower confidence intervals. Analyses were carried out in both disease types (T1DM: 2N = 814, control: 2N = 1634; T2DM: 2N = 760, control: 2N = 1784) as well as in the combined patient group (DM: 2N = 1574, control: 2N = 1800).