Table 2.
Differences in inflammatory pathways in Axl−/− MASMCs after PBS
| Pathway ID | Pathway Name | Gene Ratio, % | Pathway P Value | Gene Symbols |
|---|---|---|---|---|
| Upregulated pathways | ||||
| 604 | Cytokine-cytokine receptor interaction | 1 | 0.00116 | Cx3cl1; Il11 |
| Downregulated pathways | ||||
| 604 | Cytokine-cytokine receptor interaction | 3 | 5.05e−11 | Ccr10; Cxcl10; Il1r2; Il2rb; Il2rg; Il4; Il6ra |
| 9938 | Cytokine receptor degradation signaling (JAK-STAT pathway and regulation pathway) | 12 | 1.16e−8 | Il1r2; Il2rb; Il2rg; Il6ra |
| 9526 | Negative regulation of (phosphorylation of the cytokine receptor) in the JAK-STAT pathway (JAK-STAT pathway and regulation pathway) | 12 | 1.16e−8 | Il1r2; Il2rb; Il2rg; Il6ra |
| 9644 | Negative feedback regulation of the JAK-STAT pathway by cytokine receptor degradation signaling (JAK-STAT pathway and regulation pathway) | 10 | 2.32e−8 | Il1r2; Il2rb; Il2rg; Il6ra |
| 10320 | JAK-STAT pathway and regulation pathway | 2 | 5.54e−7 | Il1r2; Il2rb; Il2rg; Il4;Il6ra |
| 651 | JAK-STAT signaling pathway | 3 | 5.51e−6 | Il2rb; Il2rg; Il4; Il6ra |
| 9571 | IL-4 signaling pathway (JAK1, JAK3, and STAT6) and IL-4 signaling (JAK1, JAK3, and STAT6) | 33 | 1.16e−5 | Il2rg; Il4 |
| 10050 | IL-2 signaling pathway (JAK1, JAK3, and STAT5) and IL-2 signaling (JAK1, JAK3, and STAT5) | 25 | 2.16e−5 | Il2rb; Il2rg |
| 682 | Hematopoietic cell lineage | 4 | 4.34e−5 | Il1r2; Il4; Il6ra |
| 8107 | Intestinal immune network for IgA production | 5 | 0.00059 | Ccr10; Il4 |
| 4351 | Chemokine signaling pathway | 1 | 0.01065 | Ccr10; Cxcl10 |
| 4385 | Endocytosis | 1 | 0.01572 | Il2rb; Il2rg |
MASMCs, mouse aortic smooth muscle cells.