Table 4.
Downregulated pathways in Axl−/− MASMCs after interferon-γ
| Pathway ID | Pathway Name | Gene Ratio, % | Pathway P Value | Gene Symbols |
|---|---|---|---|---|
| 604 | Cytokine-cytokine receptor interaction | 6 | 1.29e−18 | Ccl11; Ccl2; Ccl5; Ccl7; Ccl8; Ccl9; Ccr10; Cxcl10; Cxcl9; Cxcr2; Cxcr5; Il13ra1; Il18; Il2rb |
| 4351 | Chemokine signaling pathway | 6 | 9.54e−15 | Ccl11; Ccl2; Ccl5; Ccl7; Ccl8; Ccl9; Ccr10; Cxcl10; Cxcl9; Cxcr2; Cxcr5 |
| 8111 | NOD-like receptor signaling pathway | 11 | 3.41e−11 | Casp1; Ccl11; Ccl2; Ccl5; Ccl7; Ccl8; Il18 |
| 8116 | Cytosolic DNA-sensing pathway | 7 | 6.15e−6 | Casp1; Ccl5; Cxcl10; Il18 |
| 11853 | Chemokine receptors bind chemokines | 14 | 1.53e−5 | Ccl5; Ccr10; Cxcr2 |
| 9938 | Cytokine receptor degradation signaling (JAK-STAT pathway and regulation pathway) | 9 | 5.33e−5 | Cxcr2; Il13ra1; Il2rb |
| 9526 | Negative regulation of phosphorylation of the cytokine receptor in the JAK-STAT pathway (JAK-STAT pathway and regulation pathway) | 9 | 5.33e−5 | Cxcr2; Il13ra1; Il2rb |
| 9644 | Negative feedback regulation of the JAK-STAT pathway by cytokine receptor degradation signaling (JAK-STAT pathway and regulation pathway) | 8 | 8.86e−5 | Cxcr2; Il13ra1; Il2rb |
| 10373 | Malaria | 6 | 0.00018 | Ccl2; Il18; Itgb2 |
| 699 | Toll-like receptor signaling pathway | 3 | 0.00143 | Ccl5; Cxcl10; Cxcl9 |
| 10401 | Chagas disease (American trypanosomiasis) | 3 | 0.00152 | C3; Ccl2; Ccl5 |
| 10320 | JAK-STAT pathway and regulation pathway | 2 | 0.00157 | Cxcr2; Il13ra1; Il18; Il2rb |
| 10352 | Staphylococcus aureus infection | 4 | 0.00575 | C3; Itgb2 |
| 11557 | Immunoregulatory interactions between a lymphoid cell and a nonlymphoid cell | 3 | 0.00767 | C3; Itgb2 |
| 10360 | Leishmaniasis | 3 | 0.00928 | C3; Itgb2 |
| 651 | JAK-STAT signaling pathway | 1 | 0.04584 | Il13ra1; Il2rb |