Table 1. Fifteen BMI loci showing significant age-differences in adults ≤50y compared to adults >50y.
The table shows the age-group specific (sex-combined) results, ordered by largest to smallest effect in adults ≤50y. All loci were detected by the screen on age-difference that included the a-priori filter on P Overall < 10−5. The age- and sex-specific results (four strata) and more detailed information on the loci are given in S4 Table.
| Age ≤ 50y | Age > 50y | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SNP | Novel Locus a | Nearest Gene | Chr | Pos | Alleles b EA/OA | EAF | β | P | N | β | P | N | PAgediff |
| rs9936385 | FTO | 16 | 52376670 | C/T | 39% | 0.093 | 4.5E-95 | 115,354 | 0.073 | 1.0E-97 | 197,478 | 1.6E-04 | |
| rs2867125 | TMEM18 | 2 | 612827 | C/T | 83% | 0.086 | 6.1E-49 | 112,934 | 0.051 | 2.3E-30 | 195,579 | 4.0E-07 | |
| rs12955983 | MC4R | 18 | 56023969 | G/A | 28% | 0.068 | 1.7E-41 | 114,448 | 0.038 | 2.0E-23 | 196,590 | 6.7E-07 | |
| rs6737082 | ADCY3 | 2 | 24991544 | C/A | 47% | 0.046 | 6.3E-20 | 92,191 | 0.022 | 5.4E-09 | 162,112 | 4.7E-05 | |
| rs2821248 | NEGR1 | 1 | 72348148 | A/G | 83% | 0.042 | 8.4E-12 | 106,067 | 0.017 | 1.9E-04 | 188,322 | 6.2E-04 | |
| rs1514174 | TNNI3K | 1 | 74765651 | C/T | 43% | 0.039 | 3.0E-15 | 92,120 | 0.012 | 1.7E-03 | 161,764 | 2.8E-06 | |
| rs591120 | SEC16B | 1 | 176169376 | C/G | 20% | 0.033 | 4.9E-14 | 115,337 | 0.014 | 2.8E-05 | 197,481 | 3.1E-04 | |
| rs11908421 | yes | CBLN4 | 20 | 53813074 | T/C | 81% | 0.033 | 8.7E-08 | 92,575 | 0.007 | 1.2E-01 | 162,284 | 4.3E-04 |
| rs4947644 | yes | DDC | 7 | 50586370 | T/C | 51% | 0.030 | 7.7E-10 | 91,980 | 0.009 | 1.7E-02 | 158,555 | 2.5E-04 |
| rs10840060 | STK33 | 11 | 8456621 | C/A | 50% | 0.029 | 3.8E-11 | 110,697 | 0.011 | 2.0E-03 | 187,808 | 4.0E-04 | |
| rs1459180 | Intergeneic | 8 | 77144822 | G/T | 58% | 0.027 | 3.1E-09 | 112,913 | 0.009 | 1.6E-02 | 190,729 | 6.0E-04 | |
| rs17747324 | TCF7L2 | 10 | 114742493 | T/C | 77% | 0.004 | 4.8E-01 | 111,572 | 0.031 | 2.6E-13 | 193,773 | 4.7E-05 | |
| rs3127574 | yes | SLC22A3 | 6 | 160711360 | C/G | 51% | 0.001 | 7.9E-01 | 113,057 | 0.019 | 2.3E-08 | 195,472 | 6.8E-04 |
| rs3769885 | yes | COBLL1 | 2 | 165300636 | A/G | 48% | -0.001 | 9.1E-01 | 107,703 | 0.020 | 3.9E-09 | 192,513 | 1.1E-04 |
| rs4420638 | APOC1 | 19 | 50114786 | A/G | 82% | -0.007 | 3.6E-01 | 83,196 | 0.040 | 8.9E-12 | 152,014 | 2.1E-07 | |
Chr: Chromosome; Pos: position; EAF: Effect Allele Frequency; EA: Effect allele; OA: Other allele
a ‘Yes’ if the locus is mentioned as BMI locus for the first time
b Effect allele is according to the BMI increasing allele according to the associated sex.