Fig. 1.

Effect of chronic antihypertensive therapy on systolic (SBP; A and B), diastolic blood pressure (DBP; C and D), and pulse pressure (E and F) in elastin-insufficient (Het) and littermate control [wild-type (WT)] mice. Pulse pressure was calculated as the difference between measured SBP and DBP. Each bar represents a different treatment group and is labeled below. H₂O was the vehicle for losartan (LOS) and propranolol (PRO), while 50% DMSO was used to dissolve nicardipine (NIC). The dotted line separates the treatment groups using different vehicles, which were analyzed independently. Each treatment group was compared with the vehicle-treated Het group in A and B or to the vehicle-treated WT group in C and D. Data are mean values ± SD; n = 5–8 mice per treatment group. Significant difference in the post hoc Dunnett's multiple comparisons test: *P < 0.05, **P < 0.005, ***P < 0.001, ****P < 0.0001, between indicated groups.