Fig. 3.
Chronic antihypertensive therapy has no effect on large artery mechanics. Pressure-diameter relationships of ascending aortas (A and C) and left common carotid arteries (B and D) from Eln+/− mice (Het) and littermates (WT) treated with various reagents: vehicle (H2O or 50% DMSO), LOS, PRO, and NIC. For A–D, solid lines represent vehicle-treated groups while dotted lines represent drug-treated groups; black represents WT while grey represents Eln+/− mice. In A and B, the black lines representing H2O-WT and DMSO-WT appear separately above all grey curves representing the 5 Het groups. Each treatment group was compared with the vehicle-treated Het group in A and B or to the vehicle-treated WT group in C and D. For E and F, the slope of the ascending aorta pressure-diameter curve between designated pressures (75–100 or 100–125 mmHg) was calculated by taking the difference in vessel outer diameter (OD) at chosen pressures and dividing it by the pressure difference (25 mmHg in this case) for the indicated treatment groups. Within each pressure range, each treatment group was compared with the vehicle-treated Het group. Data are mean values ± SD; n = 5–8 mice per treatment group. Significant difference in the post hoc Dunnett's multiple comparisons test: *P < 0.05, **P < 0.005.