Fig. 1.

A: perfusion recovery across inbred mouse strains (6 shown) and resulting haplotype map reduce the number of candidate genes within limb salvage-associated quantitative trait locus 1 (LSq-1). y-Axis shows extent of perfusion in the ischemic limb relative to the nonischemic limb; x-axis shows days (D) and weeks (W) following experimental peripheral arterial disease (PAD; n = 8–10/group). HLI, hindlimb ischemia. B: schematic of haplotype blocks shows location of single nucleotide polymorphisms within LSq-1, where C57Bl/6 = C57BlKS = CBA = DBA2 but ≠ Balb/c, A/J, 129SI/Svlm, FVB/n. Perfusion recovery for Balb/c and A/J was assessed and determined previously to be poor (9). Genes within each haplotype block are shown. ADAM12, a disintegrin and metalloproteinase gene 12.