Skip to main content
. 2015 Jul 10;309(5):H790–H803. doi: 10.1152/ajpheart.00803.2014

Fig. 2.

Fig. 2.

ADAM12 showed higher differential expression in C57Bl/6 (B6) compared with Balb/c (BC). ADAM12 (A), IL-21R (B), IL-4Ra (C), and inositol polyphosphate-5-phosphatase F (INPP5F) mRNA (D) are upregulated in ischemic hindlimbs at a higher level in C57Bl/6 than Balb/c. ADAM12 showed the highest difference in expression (>3-fold) in C57Bl/l6 compared with Balb/c [B6I, C57Bl/6 ischemic; BCI, Balb/c ischemic; B6NI, C57Bl/6 nonischemic; BCNI, Balb/c nonischemic; n = 8–10/group, *P < 0.05, not significant (NS) = P > 0.05]. E: higher expression of ADAM12 protein in ischemic hindlimb muscles of C57Bl/6 compared with Balb/c. F: quantification of blot in E (n = 4 for C57Bl/6 and 5 for Balb/c). ADAM12 protein shows the highest differential expression between C57Bl/6 and Balb/c (E and F) compared with the other differentially expressed genes [IL-21R (G and H) and IL-4R (I and J); n = 3–4/group]. INPP5F protein (K and L) did not show significant differential expression (n = 3/group, P = 0.4). HPRT, hypoxanthine guanine phosphoribosyl transferase.