Table 1.
Quantitative analysis of neural precursor markers in leptomeninges at different developmental stages.
| Vimentin+ cells | Nestin+ cells | Vimentin+/Nestin+ cells | DCX+ cells | Sox2+ cells | |
|---|---|---|---|---|---|
| E20 | 25.7% ± 4.8 (n = 4) | 23.2% ± 6.5 (n = 4) | 12.9% ± 5.1 (n = 3) | 10.5% ± 4.4 (n = 4) | 2.6% ± 1.1 (n = 3) |
| P0 | 20.6% ± 3.9 (n = 4) | 19.3% ± 5.8 (n = 4) | 8.2% ± 1.3 (n = 4) | 13.0% ± 4.1 (n = 4) | 4.2% ± 3.4 (n = 3) |
| P15 | 24.8% ± 4.5 (n = 5) | 22.8% ± 3.8 (n = 3) | 7.8% ± 1.9 (n = 3) | 4.8% ± 5.2 (n = 4) | 0.2% ± 0.3 (n = 3) |
| Young adult (6–8 weeks) | 31.0% ± 0.8 (n = 3) | 21.3% ± 3.1 (n = 3) | 8.2% ± 1.8 (n = 3) | 1.4% ± 1.1 (n = 3) | 0.5% ± 0.5 (n = 3) |
| Mature adult (24 weeks) | 32.2% ± 5.4 (n = 3) | 17.7% ± 1.4 (n = 3) | 5.5% ± 3.1 (n = 3) | 1.4% ± 0.7 (n = 3) | 0.3% ± 0.6 (n = 3) |
Quantifications were performed by counting cells lying above the pial basal lamina (visualized by laminin immunoreactivity). Numbers are expressed as the percentage of positive cells on the total number of cells counted. Data are mean ± SD; n = number of animals analyzed.