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. 2015 Oct 2;9:376. doi: 10.3389/fncel.2015.00376

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Copyright © 2015 Di Mauro, Tozzi, Calabresi, Pettorossi and Grassi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic draw showing the different influence of neo-synthesized DHT and E2 on the LFS-LTD and HFS-LTP. (A) LTD is induced in the presence of basal DHT synthesized by 5α-reductase enzyme from T (thin up arrow) and/or DHT synthesized by LFS (dashed arrow, thick up arrow). DHT exerts an inhibitory effect reverting the basal partial LTP (pLTP) into LTD. Synthesis of E2 is not involved in the LFS-LTD. but the exogenous E2 can enhance the pLTP to a full LTP. (B) pLTP is changed into a full LTP in the presence of basal E2 synthesized from T by P450-aromatase (thin up arrow) and/or E2 synthesized by HFS (dashed arrow, thick up arrow). The minor inhibitory effect of DHT on pLTP (thin arrow) might be prevented by an inhibitory influence of E2 on DHT (dotted arrow).