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Children's Cancer Group Toxicity and Complications Criteria
| Grade 1 (mild) | Grade 2 (moderate) | Grade 3 (severe) | Grade 4 (unacceptable) | |
|---|---|---|---|---|
| Hearing loss | ||||
| Objective | 20–40 db loss >4 kHz | >40 db loss >4 kHz | >40 db loss 2 kHz | >40 db loss <2 kHz |
| Subjective | Loss on audiometry only | Tinnitus, soft speech | Loss correctable with hearing aid | Deafness not correctable |
| Creatinine clearance | 75% | 50–74% | 25–49% | <25% |
