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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Curr Pharmacol Rep. 2015 Apr 22;1(5):336–345. doi: 10.1007/s40495-015-0041-y

Table 1.

Prospective observational studies of NSAID use and breast cancer outcome

Subject
Population
Type/frequency
of NSAID
Outcome
Measure(s) Used
Number of
Subjects
Diagnosis
Period
Follow-up
Period
Iowa Women’s Health Study, Postmenopausal women with invasive breast cancer (Blair et al. 2007) All NSAIDs; any frequency Breast cancer and all-cause mortality 591 1986–1992 1992–2001
Life After Cancer Epidemiology (LACE) Study, Pre- and postmenopausal women with invasive breast cancer (Kwan et al. 2007) All NSAIDs; ≥3 days/week Breast cancer recurrence 2292 1997–2000 2000–2006
Nurse’s Health Study, Pre- and postmenopausal women with stage I–III breast cancer (Holmes et al. 2010) Aspirin only; 1, 2–5, and 6–7 days/week Breast cancer mortality and distant recurrence 4164 1976–2002 1980–2006