Table 2.
Insecticidal and larvicidal activity against Anopheles gambiae of isolated compounds from Z. heitzii stem bark
| Test compound | Insecticidal activity | Larvicidal activity | ||||
|---|---|---|---|---|---|---|
| LD50 (ng/mg adult female) | 95 % CI | Slope | LD50 (μg/ml) | 95 % CI | Slope | |
| Caryophyllene oxide (1) | >1000 | 185e | 175–196 | 7.4 | ||
| Dihydronitidine (2) | > 1000 | nta | ||||
| Sesamin (3) | > 1000 | > 150 | ||||
| Pellitorine (4) | 50c | 43–57 | 1.1 | 13f | 12–14 | 4.6 |
| Mixture of 1–4 b | 34d | 28–38 | 2.2 | nta | ||
| Permethrin (positive control) | 1.9d | 1.7–2.2 | 1.9 | nta | ||
ant: not tested; bThe ratio of compounds 1–4 was 4:31:26:39; c9 experiments, each with 2x25 mosquitoes; d4 experiments, each with 2x25 mosquitoes; e5 experiments, 4 with 4x20 larvae, one with 2x20 larvae; f 4 experiments, 2 with 4x20 larvae, 2 with 2x20 larvae