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Libraries used for BoNT/B LC mAb generation.
| Library | Immunizing Antigen | Vector | Library Size | mAbs |
|---|---|---|---|---|
| Human donor libraries | BoNT/A-E Toxoid | pYD2 | >107 | 1B10.1, 1B22, 2B23, 2B25.1, 4B19, B6.1 |
| Mouse B1 * | BoNT/B1 Okra | pYD4 | 4.0 × 107 | 16B3, 18A6, 18D10, 18E5, 18F2, 19A9, 19D22, 19G6 |
| Mouse B LC | BoNT/B1 LC | pYD4 | 5.0 × 107 | 31A5, 31E2, 31G2, 31H3, 34E8 |
* Mice were immunized with BoNT/B HC fragment then boosted with the indicated holotoxin.
