Table 3.
IC50 values of selected mAbs.
| mAb | Format | IC50 (×10−9 M) a | KD for BoNT/B1LC on Yeast (×10−9M) b | Epitope Group |
|---|---|---|---|---|
| 1B10.1 | IgG | 2.09 (2.04–2.14) | 118 b (69.0–197) | 1 |
| 16B3 | scFv | 5.21 (3.04–7.39) | 0.84 (0.40–1.28) | 1 |
| 18E5 | scFv | 7.01 (6.09–7.93) | 1.00 (0.66–1.34) | 1 |
| 19D22 | scFv | 5.47 (2.48–8.46) | 9.31 (5.35–13.3) | 1 |
| 18D10 | scFv | 59.0 (54.8–63.3) | 7.53 (4.09–11.0) | 2 |
a Measured using FRET assay. 95% confidence intervals are given; b The KD of 1B10.1 IgG was measured by flow fluorimetry in a KinExA. All other KD values were measured on yeast-displayed scFv. 95% confidence intervals are given.