TABLE 1:
Endogenous substrates of TMX1 identified by mass spectrometry analysis.
| Gene name | Protein name | Entrynumber | Luminal cysteines | Predicted glycans | Protein topology |
|---|---|---|---|---|---|
| Itgb1 | Integrin β-1 | P09055 | 56 | 14 | Single-pass type I |
| Slc3a2 | 4F2 cell-surface antigen heavy chain | P10852 | 2 | 10 | Single-pass type II |
| Ece1 | Endothelin-converting enzyme 1 | Q4PZA2 | 12 | 13 | Single-pass type II |
| Lrrc59 | Leucine-rich repeat–containing protein 59 | Q922Q8 | 2 | 0 | Single-pass type II |
| Ncstn | Nicastrin | P57716 | 11 | 17 | Single-pass type I |
| Atp6ap1 | V-type proton ATPase subunit S1 | Q9R1Q9 | 2 | 8 | Single-pass type I |
| Tspan3 | Tetraspanin-3 | Q9QY33 | 6 | 4 | Multipass |
| Lrp10 | Low-density lipoprotein receptor–related protein 10 | Q7TQH7 | 30 | 4 | Single-pass type I |
| Pld4 | Phospholipase D4 | Q8BG07 | 5 | Several | Single-pass type II |